Epigenetic Reprogramming Induced Pluripotency
نویسندگان
چکیده
منابع مشابه
Epigenetic reprogramming and induced pluripotency.
The cloning of animals from adult cells has demonstrated that the developmental state of adult cells can be reprogrammed into that of embryonic cells by uncharacterized factors within the oocyte. More recently, transcription factors have been identified that can induce pluripotency in somatic cells without the use of oocytes, generating induced pluripotent stem (iPS) cells. iPS cells provide a ...
متن کاملEpigenetic mechanisms of induced pluripotency
Reprogramming of somatic cells to induced pluripotent stem cells (iPSCs) requires profound alterations in the epigenetic landscape. During reprogramming, a change in chromatin structure resets the gene expression and stabilises self-renewal. Reprogramming is a highly inefficient process, in part due to multiple epigenetic barriers. Although many epigenetic factors have already been shown to aff...
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Reprogramming to induced pluripotent stem cells (iPSCs) proceeds in a stepwise manner with reprogramming factor binding, transcription, and chromatin states changing during transitions. Evidence is emerging that epigenetic priming events early in the process may be critical for pluripotency induction later. Chromatin and its regulators are important controllers of reprogramming, and reprogrammi...
متن کاملFocus on induced pluripotency and cellular reprogramming.
T he concept of ‘induced pluripotency’ stems from research showing that embryonic and differentiated cells are genetically identical and that a handful of transcription factors are sufficient to revert the fate of any given cell. The Nobel Prize-winning discovery of transcription factor-based ‘reprogramming’ inspired many laboratories to define conditions for the derivation, expansion, and diff...
متن کاملReprogramming with defined factors: from induced pluripotency to induced transdifferentiation.
Ever since work on pluripotency induction was originally published, reporting the reprogramming of somatic cells to induced pluripotent stem cells (iPS cells) by the ectopic expression of the four transcription factors Oct4, Sox2, Klf4 and c-Myc, high expectations regarding their potential use for regenerative medicine have emerged. Very recently, the direct conversion of fibroblasts into funct...
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ژورنال
عنوان ژورنال: The Indonesian Biomedical Journal
سال: 2011
ISSN: 2355-9179,2085-3297
DOI: 10.18585/inabj.v3i2.139